Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy
نویسندگان
چکیده
منابع مشابه
Tumor-Associated Macrophage (TAM) and Angiogenesis in Human Colon Carcinoma
AIM This study aimed to clarify how macrophages affect prognosis in cancer colon and their association with tumor angiogenesis. MATERIAL AND METHODS Forty four biopsies of colon carcinoma and 15 of benign adenomatous polyps were investigated for macrophages infiltration and microvessels density using immunohistochemistry and image morphometric analysis. Macrophages and blood vessels were stai...
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The testing time for a system-on-chip(SOC) largely depends on the design of test wrappers and the test access mechanism(TAM).Wrapper/TAM co-optimization is therefore necessary to minimize SOC testing time . In this paper, we propose an efficient algorithm to construct wrappers that reduce testing time for cores. We further propose a new approach for wrapper/TAM co-optimization based on two-dime...
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Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the express...
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Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate from Ly6C(hi) monocytes. However, the mechanisms regulating the abundance and phenotype of distinct TAM subsets remain unknown. Here, we investigated the role of macrophage colony-stimulating factor (M-CSF) in TAM differentiation and pol...
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Introduction: Odontogenic cysts are osteodestructive lesions affecting the jaws. Odontogenic keratocyst is an odontogenic cyst with highly aggressive features. Multicystic ameloblastoma is a benign epithelial odontogenic tumor with more aggressive behavior than dentigerous cyst and odontogenic keratocyst. Invasion and metastasis of tumors require increased blood vessels during tumorigenesis. Th...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2020
ISSN: 2375-2548
DOI: 10.1126/sciadv.aaz8521